OVERVIEW

Thymalin is a synthetic version of thymulin, a peptide originally isolated from the thymus gland in 1977. It plays a critical role in immune system regulation, inflammation control, and overall longevity.

Research has identified Thymalin’s potential benefits in:

• Enhancing immune system function
• Reducing inflammation and chronic pain
• Prolonging lifespan and reducing mortality rates
• Supporting cardiovascular and metabolic health
• Promoting nervous system function and neuroprotection

With its wide-ranging effects, Thymalin has been extensively studied for its applications in immunology, anti-aging medicine, and chronic disease management.

RESEARCH

Immune System Modulation

• Thymalin enhances T-cell differentiation and increases natural killer (NK) cell activity.
• Research suggests it may help restore immune balance in immunocompromised patients, including HIV and chronic immune suppression cases.
• In diabetic patients with retinopathy, Thymalin boosted T-lymphocyte proliferation, reducing inflammation and slowing disease progression.
• Potential application: Immunotherapy, chronic inflammation treatment, and immune recovery support.

Anti-Aging & Longevity

• Clinical studies in elderly individuals demonstrated that long-term Thymalin administration normalized cardiovascular, immune, and nervous system functions.
• Research suggests Thymalin reduces acute respiratory diseases, hypertension, osteoporosis, ischemic heart disease, and arthritis.
• Mortality rates were reduced by up to 50% in populations receiving Thymalin therapy.
• Potential application: Longevity research, geriatric medicine, and chronic disease prevention.

Cancer Research

• Studies suggest Thymalin may enhance the immune system’s ability to combat cancer.
• When combined with pulsed laser therapy, Thymalin increased antibody production and immune activity, leading to higher remission rates in tumor-bearing mice.
• Even in sub-therapeutic doses, Thymalin demonstrated tumor-inhibiting properties, slowing cancer progression.
• Potential application: Cancer adjuvant therapy and tumor regression research.

Cardiovascular Health

• Thymalin reduces lipid levels and T-cell dysfunction, potentially preventing and reversing atherosclerosis.
• Animal studies suggest Thymalin reduces immune dysfunction that contributes to arterial plaque formation, lowering cardiovascular disease risk.
• Potential application: Atherosclerosis prevention, cardiovascular disease management, and lipid metabolism regulation.

Postoperative Recovery & Infection Prevention

• Russian clinical trials found Thymalin highly effective in preventing post-surgical infections and inflammatory complications.
• Mortality rates significantly decreased in high-risk patients receiving Thymalin therapy.
• Potential application: Postoperative recovery, infection control, and surgical immune support.

Neuroprotection & Circadian Rhythms

• Research links Thymalin to circadian rhythm regulation and seasonal immune function changes.
• May help prevent age-related immune decline and lower infection susceptibility in elderly individuals.
• Potential application: Neurological disease prevention, circadian rhythm stabilization, and immune aging management.

Chronic Disease Applications

• Tuberculosis: Clinical trials found that patients receiving Thymalin alongside standard antibiotic therapy had higher cure rates than those on antibiotics alone.
• Kidney Disease: Research suggests Thymalin reduces inflammation and improves kidney function in patients with chronic glomerulonephritis.
• Psoriasis: Studies indicate that Thymalin reduces inflammation and improves skin healing in psoriasis patients.
• Potential application: Adjunct therapy for infectious diseases, kidney health, and autoimmune disorders.

STRUCTURE

• Amino Acid Sequence: Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
• Molecular Formula: C₃₃H₅₄N₁₂O₁₅
• Molecular Weight: 858.864 g/mol
• CAS Registry Number: 63958-90-7
• Synonyms: Thymulin, Thymic Factor, Serum Thymic Factor

CITATIONS

1. V. K. Khavinson & V. G. Morozov Peptides of the pineal gland and thymus prolong human life. Neuro Endocrinol. Lett. (2003).
2. J. Bach et al. Biochemical characterization of a serum thymic factor. Nature (1977).
3. A. M. Reznichenko et al. Changes in immune cell indexes under the influence of Thymalin in patients with hyperplastic thyroid disease. Klin. Khir. (2001).
4. T. P. Young. Immune mechanisms in HIV infection. J. Assoc. Nurses AIDS Care (2003).
5. A. P. Kozlov & K. G. Moskalik. Pulsed laser radiation therapy of skin tumors. Cancer (1980).
6. N. N. Tretiak et al. Efficacy of Thymalin and plasmapheresis in treating chronic lymphocytic leukemia patients.Lik. Sprava (1998).
7. M. A. Karachunskiĭ et al. Cellular immunity changes in pulmonary tuberculosis patients with diabetes mellitus.Probl. Tuberk. (1997).
8. G. V. Budazhabon et al. Thymalin’s effect on immune responses in chronic glomerulonephritis. Ter. Arkh. (1984).
9. V. E. Ryzhenkov et al. Thymalin’s role in preventing experimental hyperlipidemia and atherosclerosis. Vopr. Med. Khim. (1988).
10. S. Wade et al. Thymulin (Zn-facteur thymique serique) activity in anorexia nervosa patients. Am. J. Clin. Nutr. (1985).