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THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused, or mislabeled as a drug, food, or cosmetic.

Melanotan 2 10mg

Melanotan-2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH), originally developed in the 1980s.

$45.00

Peptides will arrive in a lyophilized (powder) form for maximum stability

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OVERVIEW

Melanotan-2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH), originally developed in the 1980s. It is known for its ability to:

  • Enhance sexual arousal
  • Regulate compulsive and addictive behaviors
  • Suppress appetite and reduce fat storage
  • Increase melanin production, leading to a tanning effect
  • Possibly influence neurodevelopmental conditions like autism when used in early stages

MT-2 exerts its effects by binding to melanocortin receptors, primarily MC-1R and MC-4R, which are involved in pigmentation, metabolic regulation, and sexual function.

RESEARCH

Melanotan-2 and Melanocortin Receptor Activation

MT-2 interacts with five known melanocortin receptors (MCRs), each serving distinct functions:

  • MC-1R: Found in melanocytes, responsible for skin and hair pigmentation.
  • MC-2R: Located in the adrenal glands, involved in cortisol and adrenal hormone secretion.
  • MC-3R: Regulates appetite and energy metabolism.
  • MC-4R: Plays a role in food intake, sexual behavior, and metabolic balance.
  • MC-5R: Expressed in sweat glands and pancreatic islet cells, contributing to sebum production and insulin function.

MT-2 and Autism Research

Recent studies suggest that Melanotan-2 may influence autism-related behaviors in animal models. Research has shown that MT-2:

  • Enhances oxytocin receptor expression in key brain regions.
  • Improves social interaction and communication in autism spectrum disorder (ASD) models.

These findings suggest that MT-2 may modulate oxytocin pathways, which play a role in social bonding and emotional regulation.

MT-2 and Appetite Suppression

Melanotan-2 has been found to reduce hunger and fat storage by activating MC-4R receptors in the hypothalamus. Research indicates that:

  • Mice treated with MT-2 significantly decreased food intake and changed their dietary preferences.
  • MT-2 reduced cravings for high-fat foods, which are typically preferred in normal conditions.
  • It mimics leptin (the satiety hormone) but appears to be more effective in controlling hunger.

These findings highlight the potential of Melanotan-2 as a therapeutic tool for obesity management.

MT-2 and Diabetes Management

MT-2 has been studied for its potential role in blood sugar regulation, with findings suggesting that it can:

  • Lower blood glucose levels.
  • Reduce glucagon secretion, which helps regulate blood sugar.
  • Inhibit ketone body production, potentially preventing complications associated with diabetes.

Unlike leptin, MT-2 can cross the blood-brain barrier in significant amounts, making it a more promising candidate for metabolic regulation.

MT-2 and Addiction/Impulse Control

Research suggests that Melanotan-2 may help regulate impulse control and reduce addictive behaviors, particularly in alcohol dependency. Studies have shown:

  • Rats treated with MT-2 significantly reduced alcohol consumption and instead chose water.
  • MT-2 enhances the effects of naltrexone, a common anti-addiction medication, reducing binge drinking behaviors in mice.

These findings indicate that MT-2 may hold potential for treating alcoholism and other impulse-control disorders.

MT-2 and Erectile Dysfunction

One of the earliest research areas for Melanotan-2 was its role in treating erectile dysfunction (ED). Key findings include:

  • MT-2 proved effective in men who did not respond to sildenafil (Viagra).
  • Up to 80% of men who failed Viagra treatment showed positive results with MT-2.
  • It works through central nervous system pathways, making it beneficial for both male and female sexual dysfunction.

These studies suggest that Melanotan-2 may be a viable alternative for individuals with treatment-resistant ED.

STRUCTURE

  • Molecular Formula: C₅₀H₆₉N₁₅O₉
  • Molecular Weight: 1024.198 g/mol
  • Amino Acid Sequence: Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)
  • CAS Registry Number: 121062-08-6
  • PubChem Identifier: 92432

CITATIONS

  1. Minakova E. et al. Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism. PLoS ONE (2019).
  2. van der Klaauw A. et al. Role of melanocortin signaling in the preference for dietary macronutrients in human beings. Lancet Lond. Engl. (2015).
  3. Shimizu H., Inoue K., Mori M. The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure. J. Endocrinol. (2007).
  4. Bjørbaek C., Hollenberg A. N. Leptin and melanocortin signaling in the hypothalamus. Vitam. Horm. (2002).
  5. Guo F., Bakal K., Minokoshi Y., Hollenberg A. N. Leptin Signaling Targets the Thyrotropin-Releasing Hormone Gene Promoter in Vivo. Endocrinology (2004).
  6. Lee Y. H., Wang M. Y., Yu X. X., Unger R. H. Glucagon is the key factor in the development of diabetes.Diabetologia (2016).
  7. Toda C. et al. Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes (2009).
  8. York D. A., Boghossian S., Park-York M. Melanocortin activity in the amygdala influences alcohol intake.Pharmacol. Biochem. Behav. (2011).
  9. Navarro M., Carvajal F., Lerma-Cabrera J. M., Cubero I., Picker M. J., Thiele T. E. Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice. Alcohol. Clin. Exp. Res. (2015).
  10. Wessells H. et al. MT-II Induces Penile Erection via Brain and Spinal Mechanisms. Annals of the New York Academy of Sciences (2003).
  11. Wessells H. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: Double-blind placebo-controlled crossover study. Nature (1998).
  12. Lau J. K. Y. et al. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Scientific Reports (2021).

 

OVERVIEW

Melanotan-2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH), originally developed in the 1980s. It is known for its ability to:

  • Enhance sexual arousal
  • Regulate compulsive and addictive behaviors
  • Suppress appetite and reduce fat storage
  • Increase melanin production, leading to a tanning effect
  • Possibly influence neurodevelopmental conditions like autism when used in early stages

MT-2 exerts its effects by binding to melanocortin receptors, primarily MC-1R and MC-4R, which are involved in pigmentation, metabolic regulation, and sexual function.

RESEARCH

Melanotan-2 and Melanocortin Receptor Activation

MT-2 interacts with five known melanocortin receptors (MCRs), each serving distinct functions:

  • MC-1R: Found in melanocytes, responsible for skin and hair pigmentation.
  • MC-2R: Located in the adrenal glands, involved in cortisol and adrenal hormone secretion.
  • MC-3R: Regulates appetite and energy metabolism.
  • MC-4R: Plays a role in food intake, sexual behavior, and metabolic balance.
  • MC-5R: Expressed in sweat glands and pancreatic islet cells, contributing to sebum production and insulin function.

MT-2 and Autism Research

Recent studies suggest that Melanotan-2 may influence autism-related behaviors in animal models. Research has shown that MT-2:

  • Enhances oxytocin receptor expression in key brain regions.
  • Improves social interaction and communication in autism spectrum disorder (ASD) models.

These findings suggest that MT-2 may modulate oxytocin pathways, which play a role in social bonding and emotional regulation.

MT-2 and Appetite Suppression

Melanotan-2 has been found to reduce hunger and fat storage by activating MC-4R receptors in the hypothalamus. Research indicates that:

  • Mice treated with MT-2 significantly decreased food intake and changed their dietary preferences.
  • MT-2 reduced cravings for high-fat foods, which are typically preferred in normal conditions.
  • It mimics leptin (the satiety hormone) but appears to be more effective in controlling hunger.

These findings highlight the potential of Melanotan-2 as a therapeutic tool for obesity management.

MT-2 and Diabetes Management

MT-2 has been studied for its potential role in blood sugar regulation, with findings suggesting that it can:

  • Lower blood glucose levels.
  • Reduce glucagon secretion, which helps regulate blood sugar.
  • Inhibit ketone body production, potentially preventing complications associated with diabetes.

Unlike leptin, MT-2 can cross the blood-brain barrier in significant amounts, making it a more promising candidate for metabolic regulation.

MT-2 and Addiction/Impulse Control

Research suggests that Melanotan-2 may help regulate impulse control and reduce addictive behaviors, particularly in alcohol dependency. Studies have shown:

  • Rats treated with MT-2 significantly reduced alcohol consumption and instead chose water.
  • MT-2 enhances the effects of naltrexone, a common anti-addiction medication, reducing binge drinking behaviors in mice.

These findings indicate that MT-2 may hold potential for treating alcoholism and other impulse-control disorders.

MT-2 and Erectile Dysfunction

One of the earliest research areas for Melanotan-2 was its role in treating erectile dysfunction (ED). Key findings include:

  • MT-2 proved effective in men who did not respond to sildenafil (Viagra).
  • Up to 80% of men who failed Viagra treatment showed positive results with MT-2.
  • It works through central nervous system pathways, making it beneficial for both male and female sexual dysfunction.

These studies suggest that Melanotan-2 may be a viable alternative for individuals with treatment-resistant ED.

STRUCTURE

  • Molecular Formula: C₅₀H₆₉N₁₅O₉
  • Molecular Weight: 1024.198 g/mol
  • Amino Acid Sequence: Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)
  • CAS Registry Number: 121062-08-6
  • PubChem Identifier: 92432

CITATIONS

  1. Minakova E. et al. Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism. PLoS ONE (2019).
  2. van der Klaauw A. et al. Role of melanocortin signaling in the preference for dietary macronutrients in human beings. Lancet Lond. Engl. (2015).
  3. Shimizu H., Inoue K., Mori M. The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure. J. Endocrinol. (2007).
  4. Bjørbaek C., Hollenberg A. N. Leptin and melanocortin signaling in the hypothalamus. Vitam. Horm. (2002).
  5. Guo F., Bakal K., Minokoshi Y., Hollenberg A. N. Leptin Signaling Targets the Thyrotropin-Releasing Hormone Gene Promoter in Vivo. Endocrinology (2004).
  6. Lee Y. H., Wang M. Y., Yu X. X., Unger R. H. Glucagon is the key factor in the development of diabetes.Diabetologia (2016).
  7. Toda C. et al. Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes (2009).
  8. York D. A., Boghossian S., Park-York M. Melanocortin activity in the amygdala influences alcohol intake.Pharmacol. Biochem. Behav. (2011).
  9. Navarro M., Carvajal F., Lerma-Cabrera J. M., Cubero I., Picker M. J., Thiele T. E. Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice. Alcohol. Clin. Exp. Res. (2015).
  10. Wessells H. et al. MT-II Induces Penile Erection via Brain and Spinal Mechanisms. Annals of the New York Academy of Sciences (2003).
  11. Wessells H. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: Double-blind placebo-controlled crossover study. Nature (1998).
  12. Lau J. K. Y. et al. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Scientific Reports (2021).

 

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