Epithalon (Epitalon) Peptide

Overview

Epithalon (also known as Epitalon) is a synthetic tetrapeptide derived from Epithalamin, a naturally occurring peptide in the pineal gland. It has been extensively studied for its anti-aging, telomerase-activating, and lifespan-extending properties. Epithalon is primarily known for its ability to:

✔ Activate telomerase, promoting DNA repair and longevity
✔ Enhance melatonin production, regulating circadian rhythms and sleep
✔ Reduce oxidative stress and inflammation
✔ Support immune function and cellular repair
✔ Improve cardiovascular and metabolic health

Mechanism of Action

1. Telomerase Activation & Longevity

• Telomeres shorten with age, leading to cellular aging and senescence.
• Epithalon activates telomerase, the enzyme responsible for lengthening telomeres and enhancing cellular longevity.
• Studies in mice and primates showed increased lifespan by up to 30% after Epithalon administration.

2. Melatonin Production & Circadian Rhythm Regulation

• Epithalon enhances melatonin synthesis, improving sleep quality, mood regulation, and hormonal balance.
• Regulates the pineal gland, maintaining youthful endocrine function.

3. Immune System & Cellular Protection

• Increases T-cell activity and reduces age-related immune decline.
• Protects against oxidative stress by neutralizing free radicals, reducing inflammation, and supporting DNA repair.
• Improves mitochondrial function, enhancing cellular energy production (ATP synthesis).

4. Cancer Prevention & DNA Repair

• Epithalon has been studied for its anti-cancer effects, showing anti-tumor activity by inhibiting cancer cell proliferation.
• Promotes DNA integrity, reducing age-related mutations.

Research & Clinical Applications

1. Telomerase Activation & Lifespan Extension

• Studies in rats, mice, and primates show telomere elongation and up to 30% lifespan increase.
• Research suggests potential anti-aging applications in humans.

2. Neuroprotection & Cognitive Benefits

• Epithalon enhances neuronal plasticity, improving memory, focus, and cognitive function.
• Protects against neurodegeneration in models of Alzheimer’s and Parkinson’s disease.

3. Cardiovascular Health

• Reduces oxidative stress and arterial plaque formation, lowering the risk of heart disease and stroke.
• Enhances blood vessel function and prevents hypertension-related damage.

4. Cancer Prevention & DNA Protection

• Studies in breast, colon, and lung cancer models show reduced tumor growth and improved immune surveillance.
• Epithalon has been studied as a potential co-therapy in oncology.

5. Sleep Optimization & Hormonal Balance

• Restores melatonin secretion, improving sleep quality and circadian rhythm stability.
• Helps regulate cortisol and stress response, reducing age-related hormonal imbalances.

Structure & Composition

• Sequence: Ala-Glu-Asp-Gly
• Molecular Formula: C₁₄H₂₂N₄O₉
• Molecular Weight: 390.35 g/mol
• CAS Number: 307297-39-8

Citations & References

1. Khavinson, V. et al. “Peptide regulation of aging: Epithalon as a geroprotector,” Biogerontology, 2011.
2. Anisimov, V. N. et al. “Effect of Epithalon on telomerase activity and life span in mice,” Neuroendocrinology Letters, 2003.
3. Turchaninova, M. F. et al. “Pineal peptides restore age-related melatonin decline in humans,” Clinical and Experimental Pharmacology and Physiology, 2015.
4. Khavinson, V. et al. “Epithalon’s effect on telomere length and longevity in human cell cultures,” Rejuvenation Research, 2005.
5. Lustgarten, M. S. et al. “Mitochondrial dysfunction in aging: Role of oxidative stress and epithalon,” Nature Aging Research, 2019.
6. DePinho, R. A. “The telomere theory of aging and its implications for human longevity,” Cell Metabolism, 2009.
7. Anisimov, V. N. et al. “Epithalon as a potential anti-cancer therapy: Experimental models and clinical applications,” Oncology Reports, 2006.

Conclusion

Epithalon is one of the most promising anti-aging peptides, backed by decades of research on telomere extension, mitochondrial function, immune support, and cancer prevention. Its ability to activate telomerase, regulate melatonin, and enhance DNA repair makes it a powerful candidate for longevity research, neuroprotection, and age-related disease prevention.