OVERVIEW

L-Glutathione (GSH) is a powerful antioxidant and detoxifier that protects cells from oxidative stress, supports immune health, and plays a key role in anti-aging. It is a tripeptide composed of cysteine, glutamate, and glycine, essential for maintaining cellular redox balance and detoxification.

Key Benefits of L-Glutathione Research:

✔️ Supports brain health and reduces neurodegenerative risk
✔️ Protects cartilage and joints from oxidative damage
✔️ Enhances immune system function
✔️ Improves skin health and brightens complexion
✔️ Aids liver detoxification and heavy metal removal

GSH is widely studied in longevity research, immune function, and chronic disease prevention.

RESEARCH

1. Neuroprotection & Brain Health

• L-Glutathione shields neurons from oxidative stress, reducing the risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s.
• Low GSH levels correlate with cognitive decline and increased oxidative brain damage.
• Potential application: Brain health support, cognitive enhancement, and neuroprotection.

2. Cartilage & Joint Health

• GSH plays a role in cartilage regeneration and protects against osteoporosis and osteoarthritis.
• It regulates inflammation and oxidative stress, preventing joint degeneration.
• Potential application: Joint health, arthritis prevention, and cartilage repair.

3. Eye Health & Vision Protection

• Glutathione is present in high concentrations in the eye, particularly in the retina and lens.
• It prevents cataracts and age-related macular degeneration (AMD) by neutralizing free radicals and UV damage.
• Potential application: Vision preservation and eye disease prevention.

4. Immune System Enhancement

• GSH is critical for T-cell function and white blood cell activation, boosting immune defense.
• It has been studied for its role in improving immune response in HIV and viral infections.
• Potential application: Immune support and infection prevention.

5. Skin Health & Anti-Aging

• Glutathione reduces oxidative stress, promoting youthful skin, improved elasticity, and reduced wrinkles.
• **It lightens pigmentation by inhibiting melanin production, resulting in a brighter, more even complexion.
• Potential application: Skin rejuvenation, anti-aging, and hyperpigmentation reduction.

6. Liver Detoxification & Heavy Metal Removal

• L-Glutathione is essential for detoxifying harmful toxins, including heavy metals, alcohol, and environmental pollutants.
• It enhances liver function and prevents oxidative liver damage.
• Potential application: Liver detoxification, alcohol recovery, and toxin elimination.

7. Oxidative Stress & Inflammation Control

• GSH neutralizes harmful free radicals that contribute to chronic inflammation, aging, and disease progression.
• Low GSH levels are associated with diabetes, cardiovascular disease, and metabolic disorders.
• Potential application: Inflammation reduction and metabolic health support.

STRUCTURE

• Amino Acid Sequence: γ-L-Glutamyl-L-cysteinyl-glycine
• Molecular Formula: C₁₀H₁₇N₃O₆S
• Molecular Weight: 307.33 g/mol
• CAS Registry Number: 170-18-8
• Synonyms: GSH, Glutathione, Isethion

CITATIONS

1. H. J. Forman et al. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol. Aspects Med. (2009).
2. G. Teskey et al. Glutathione as a Marker for Human Disease. Adv. Clin. Chem. (2018).
3. S. Tsunoda et al. Protein folding and glutathione depletion in the endoplasmic reticulum. eLife (2014).
4. J. H. Wu & G. Batist. Glutathione and therapeutic potentials. Biochim. Biophys. Acta (2013).
5. T. S. Nagapan et al. L-Glutathione prevents UVB-induced melanogenesis and oxidative stress. Exp. Anim. (2019).
6. A. Bansal & M. C. Simon. Glutathione metabolism in cancer progression. J. Cell Biol. (2018).
7. P. Maher. The effects of stress and aging on glutathione metabolism. Ageing Res. Rev. (2005).
8. V. N. Reddy. Glutathione and its function in the lens. Exp. Eye Res. (1990).
9. S. Weschawalit et al. Glutathione’s anti-aging and antimelanogenic effects. Clin. Cosmet. Investig. Dermatol. (2017).
10. W. Dröge & R. Breitkreutz. Glutathione and immune function. Proc. Nutr. Soc. (2000).